The health and social care system in Wales faces a complex and multifaceted set of challenges, which were exacerbated by the coronavirus pandemic. As the immediate pressures subside, the health and social care system will be faced with a variety of systemic and workforce related challenges, in the context of challenging population health needs. Many of these are decade-old issues. The WCPP is working with the sector to explore how, in this context, the sector can deliver on the ambitions for a ‘transformation’ in the provision of health and care.